Hepatotoxic Effects of the Methanol Extract of Senna Siemea in Wister Rats - Crimson Publishers

Hepatotoxic Effects of the Methanol Extract of Senna Siemea in Wister Rats by Eze SOO* in Crimson Publishers: Peer Reviewed Material Science Journals

Senna siamea is a plant used in the tradomedicinal practice for the treatment of malaria. Despite its efficacy, there is no scientific information concerning the safety of the plant extract on the liver hence, the study evaluated the effect of the methanol extract on liver function enzymes in wistar albino rats. Thirty two rats weighing between 180-210g were randomly grouped into four of 8 rats each. Group 1(control group) received normal saline, while groups 2, 3 and 4 received orally 100, 200 and 400mg/kg/body weight of the extract. Two animals were sacrificed on weeks 1, 2, 3 and 4 respectively and both blood and organ samples were collected.

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