Collagen-The Biomaterial-Crimson Publishers



Collagen-The Biomaterial by Lavanya Gunamalai in Research & Development in Material Science

Collagen-The biomaterials for their enhanced biocompatibility and improved controllable biodegradability has immense and vital role in biomedical field for Drug and gene carrier, tissue engineering and wound dressing [1-4]. Collagen acts as a structural scaffold in tissues. Collagen scaffolds have also shown to accurately deliver cells, proteins, drugs and nucleic acids on a predictable and long-term basis Sano A et al. [5]. Finally, a recent clinical trial using adenovirus in collagen gel has cleared the path for future clinical studies on gene therapy delivered by collagen matrix Muller WE [6]. Because of collagen’s biodegradability and low immunogenicity nature, collagen is used as substrate for topical and internal pharmaceutical application. The evidence from recent studies shows the importance, diverse applications and benefits of implants delivering antibiotics Adhirajan [7]. The delivery properties of collagen-based biomaterials also display great potential for ulcer treatment and abdominal wall defect reconstruction Jaynthy C [8]. Collagen plays a key role in each phase of wound healing. The issues of elevated levels of MMPs are main problem in wound dressing. This problem is addressed uniquely by Collagen which acts as a ‘‘sacrificial substrate’. In addition, collagen based dressings have the ability to absorb wound exudates and maintain a moist wound environment. Cyclodextrins are non-toxic bucket-shaped oligosaccharides produced from starch

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