Film Dosage Forms Prepared with Alginate for Oral Candidiasis Treatment - Crimson Publishers

Film Dosage Forms Prepared with Alginate for Oral Candidiasis Treatment by Yoshifumi Murata* in Crimson Publishers: Peer Reviewed Material Science Journals

A film dosage form (FD) incorporating an antifungal agent, miconazole, was prepared with sodium alginate for the treatment of Candida infections. To ensure the safety of oral administration, FD was modified with additives, such as alginate hydrolysate, to control the drug dissolution rate. A soft film with a thickness of approximately 70μm was obtained and each FD was sufficiently strong to be applied by hand. FD immediately swelled in limited dissolution medium and then disintegrated to release the incorporated drug. The drug dissolution rate was controlled by the amount of additive in the film base solution. FD prepared with sodium alginate and the hydrolysate is useful for the treatment of oral candidiasis as the dosage form can be administered into the oral cavity to act directly on the affected site.

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